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Mrs. Wheeler only appeared in "She Blinded Me With Card Games". She has a very deep masculine voice, sounding like Dr. Girlfriend from The Venture Brothers, making Serenity think she is her father. She's also the one who paid for Serenity's operation, which ended in failure (at least temporarily). She attempted to calm Serenity down with the sound of her voice, but failed to get the door open.

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